Guadalupe Medina Serna, age 74, of Karnes City, TX passed away on Friday, December 13, 2024 in San Antonio, TX.  Guadalupe was born on January 4, 1950 in Charco, TX to the late Eliberto and Gregoria Ramirez Medina.  She was a loving wife, mother, grandmother, great-grandmother and of the Catholic Faith.  She is preceded in death by her parents, Eliberto and Gregoria Ramirez Medina; sister, Mary Ann Serna; and brothers, Juan Medina and Barnie Medina.  She is survived by her daughter, Melba Serna De La Garza of Runge; sons, Tony Serna and wife Ramona of Karnes City, Dylan Medina of Karnes City; brother, Lucio Medina of El Paso, 3 grandchildren and 2 great-grandchildren.  A Holy Rosary will be recited Thursday, December 19, 2024 at 10:30 AM with Services following immediately at 11:00 AM in the Eckols Funeral Home Chapel with Deacon Guadalupe Cantu officiating.  Interment will follow in the Charco Cemetery in Charco, TX.

Serving as Pallbearers will be Jose Pineda, Terry Palacios, Jasper DeLuna, Tony Serna and Dylan Medina.